Brain and Cognitive Development

This study evaluates whether the association between breastfeeding duration and improved childhood cognitive development can be explained by socioeconomic position (SEP) and maternal cognitive ability. The study uses multivariable linear mixed-effects models to compare verbal and spatial cognitive scores at ages 5, 7, 11, and 14 with reported breastfeeding durations. At all ages, longer breastfeeding durations were associated with higher cognitive scores after accounting for the child’s own characteristics, however the effect was modest. Adjustment for SEP approximately halved the effect sizes.

Pereyra-Elias, R., Quigley, M., Carson, C. (2022). To what extent does confounding explain the association between breastfeeding duration and cognitive development up to age 14? Findings from the UK Millennium Cohort Study. https://doi.org/10.1371/journal.pone.0267326

Preterm nutrition and neurodevelopmental outcomes

Preterm infants are at increased risk of alterations in brain structure and connectivity and subsequent neurocognitive impairment. This study explores the extent to which breastmilk exposure is associated with improved markers of brain development and connectivity in preterm infants at term equivalent age. Findings from an analysis of data on 47 preterm infants’ neonatal breastmilk exposure and brain MRI suggests that breastmilk feeding in the weeks after preterm birth is associated with improved structural connectivity of developing networks and greater fractional anisotropy  in major white matter fasciculi.

Blesa M, Sullivan G, Anblagan D, Telford EJ, Quigley AJ, Sparrow SA, Serag A, Semple SI, Bastin ME, Boardman JP. Early breast milk exposure modifies brain connectivity in preterm infants. Neuroimage. 2019 Jan 1;184:431-439. doi: 10.1016/j.neuroimage.2018.09.045. Epub 2018 Sep 18. PMID: 30240903.